Twenty-five years after the original series of murders in Woodsboro, a new killer emerges, and Sidney Prescott must return to uncover the truth.Returning cast MembersSee the original Scream (1996) cast returning to reprise their roles:Neve Campbell As Sidney PrescottCourteney Cox As Gale WeathersDavid Arquette As Dewey RileyMeet some of the new faces joining the cast for Scream 2022:Jack Quaid As Richie Kirsch - Best known for portraying Hughie in Prime Video's The BoysDylan Minette As Wes Hicks - Best known for playing the lead character Clay Jensen in 13 Reason Why