Oral Bioavailability Assessment : John Wiley & Sons, Inc. : 9781118916698 : 1118916697 : 01 Aug 2017 : Specifically geared to personnel in the pharmaceutical and biotechnology industries, this book describes the basics and challenges of oral bioavailability ? one of the most significant hurdles in drug discovery and development. ?    Describes approaches to assess pharmacokinetics and how drug efflux and uptake transporters impact oral bioavailability ?    Helps readers reduce the failure rate of drug candidates when transitioning from the bench to the clinic during development ?    Explains how preclinical animal models ? used in preclinical testing ? and in vitro tools translate to humans, which is an underappreciated and complicated area of drug development ?    Includes chapters about pharmacokinetic  modelling, the Biopharmaceutics Drug Disposition Classification System (BDDCS), and the Extended Clearance Classification System (ECCS) ?    Has tutorials for applying strategies to