Melatonin : Nova Science Publishers : 9781536129878 : 1536129879 : 01 Dec 2017 : In this compilation, the authors review pre-analytical procedures, as well as analytical conditions, to determine melatonin in both biological and non-biological samples. Several procedures for the extraction of melatonin have been described, including ultrasound-assisted extraction, liquidliquid extraction, and solid phase extraction. Following this, a study is presented wherein melatonin administration in middle-age rats was able to recover prostatic morphology and strongly decrease amiloyd bodies deposition even after obesity induction. These results were probably related to total GST activity improvement. The authors maintain that melatonin should be used as benign prostate hyperplasia chemoprevention due to decreased cell proliferation, even in hyperlipidemic medium. The functions of melatonin receptors in health and disease are reviewed, with specific references to their involvement in mood, anxiety-