Clinical Management and Challenges in Polytrauma : Mdpi AG : 9783036551395 : 3036551395 : 26 Aug 2022 : Trauma is still a leading cause of death in patients below 40 years of age. Clinical management of severely injured patients is challenging in all phases of treatment during the clinical course. Numerous factors, such as injury severity, injury pattern, patient characteristics and trauma system, affect the decision-making process in our patients. After the successful initial management of an unstable multiply injured patient, secondary definitive surgeries and reconstructions may have a risk for further systemic complications and the deterioration of the patient's physiology. A "Safe Definitive Surgery" (SDS) concept considers the dynamics of the clinical course (prehospital, operations, complications, etc.) and the patient's physiology. Due to the repeated re-evaluation and assessment of the patient's clinical course, dynamics and adaptation of the treatment strategy, the safe manag