Artificial Nanopatterned Biointerfaces for Medical Applications : 9783639081787 : 03 Sep 2008 : The interactions occurring between biological systems and the surface of biomaterials has been an area of strong research focus for a number of decades. There has been a realisation of the importance of macromolecular interactions and a consequent need to understand biointerfacial events at the nanometer length-scale. A set of tools for working at the nanometer scale are critical for the study, design and evaluation of new biomaterials. In this work colloidal lithography as a versatile nanofabrication route is extended from metals and ceramics for use with organic materials including polymers and proteins. Large area arrays of systematic controlled topographic/chemical/protein nanopatterns are demonstrated. Artificial nanostructured biointerfaces produced by these approaches were used to study the influence of nanoscale surface structures on the behaviour of adherent cells