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Unleash your full potential with Styrkr GEL30 Nitro Dual-Carb Energy Gel. Designed for the relentless athlete, this gel is a powerhouse of energy, blending maximum carbohydrates with a nitric oxide boost to shatter your personal bests. Fuel your endurance with GEL30 Nitro+. It's more than just an energy gel; it's a scientific breakthrough in sports nutrition:Peak Performance: Enhanced with 30g of dual-carbs, ensuring rapid and sustained energy release.Instant Power Boost: Natural nitrates, including Beetroot and Amaranthus leaf extracts, elevate oxygen efficiency for stronger, longer workouts.Superior Taste and Texture: Natural flavouring and improved texture for an enjoyable fuelling experience.Stomach-Friendly: pH-balanced with no unnecessary preservatives, gentle on your stomach during intense activities.Eco-Conscious Packaging: Thoughtfully designed with 35% less plastic, reflecting our commitment to the environment.The Styrkr GEL30 Nitro Dual-Carb Energy Gel isn't just about endur

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pIn the first part of this book I discussed how the human brainppdeveloped due to the development of languageppIn the second and third part, I analyzed all aspects which areppmentioned below.pp- prehistoric humans lived in a terrestrial atmosphere wereppC14 isotope concentration was intermittently higher thanppusual because a chain of geomagnetic events occurred inppthis epochpp- the C14 isotopes were incorporated into plants, andpptransmitted by ingestion to animals in the form of C14-Glucosepp- biological processes involving C14-Glucose in humansppconducted to a reduction of organic production of nitric oxidepp- a lesser apport of nitric oxide favored a healthier cellularppdevelopment that decreased the sensitivity to viruses andpppathogens this aspect helped humans to migrate and betterppadapt to new environmentspp- but for the most of it, the decline of nitric oxide led to significantppincreases in neurogenesis that stimulated the brain plasticity, ppbut also, it favored a chain of

The Story of Homo Loquens | Mrejeru Dan M. | Copertă tare

A compelling novel based on the high-stakes biotech industry and the science behind Viagra from the internationally known Father of the Pill. br The fourth installment of Carl Djerassi s pioneering science-in-fiction tetralogy tells the story of a husband and wife team who devise new solutions to problems associated with sex and reproduction. Renu Krishnan is an Indian-born, American-educated scientist who discovers how NO nitric oxide can help men with erectile dysfunction the scientific rationale behind Viagra. At the same time, her husband, Israeli scientist Jephtah Cohn, develops a new approach to ovulation prediction, which is also based on factual research. When Wall street gets wind of their discoveries, the couple catapults in the fast paced world of lawyers and IPOs, where scientists are now a hot commodity. Deftly exploring the demanding worlds of academia and high finance, Djerassi brings back many characters from his three earlier novels for a satisfying conclusion.

No | Djerassi Carl | Copertă tare

pThis edited volumeaims to describe physiological and pathophysiological mechanisms that underlie human maternal-fetal interactions. The book emphasizes the structure and development of the fetoplacental unit, the endocrine and nutritional regulation of fetal development, nitric oxide signalling, solute carriers function and ion channels regulation in healthy pregnancies and diseases, like preeclampsia, gestational diabetes, and maternal obesity, among others. Also, we highlight novel mechanisms associated with language impairment in children, the use of serotonin inhibitors or cannabis during pregnancy, and maternal conditions' potential impact on cerebrovascular development in newborns and infants. The cellular and molecular understanding of maternal-fetal physiology and pathophysiology will allow the readers to understand the impact of diseases or conditions that are highly prevalent in pregnant women.brp

Advances in Maternal | Fetal Biomedicine: Cellular and Molecular Mechanisms of Pregnancy Pathologies | Gonzalez | Ortiz Marcelo | Copertă tare

pThis book covers recent pre-clinical and clinical developments in gasotransmitters nitric oxide, carbon monoxide and hydrogen sulfide in all transplantable solid organs - kidney, heart, lung, liver, pancreas and intestine. Gasotransmitters are a class of small endogenously produced gaseous signaling molecules that play important roles in cellular homeostasis and impact physiological and pathophysiological situations. Recently, these gasotransmitters have emerged as potent cytoprotective mediators, possessing therapeutic properties that enable them exhibit their intracellular signaling functions. Hence, alterations in their physiological levels have been associated with various pathologies including cold ischemia-reperfusion injury IRI in organ transplantation. ppbrppIn the context of organ transplantation, a novel therapeutic strategy that is being investigated involves administration of these gasotransmitters to the organ donor or recipient before or after transplantation, or supplem

Gasotransmitters in Organ Transplantation: A New Era in Transplant Medicine | Dugbartey George J. | Copertă tare

The majority of medicines presently in use have their origins in plant sources. Plant-derived compounds contain immunomodulatory properties that make them appropriate for use in drug development. Plant polysaccharides including aa fruit, ganoderma lucidum and cordyceps sinensis exhibit immunostimulatory or immunomodulatory properties. Flavonoids which include flavonones, isoflavone, xanthones, flavones and flavonols are found in nearly all plants and have a variety of bioactive qualities. Proteins derived from certain herbs are utilized as natural protein supplements for convalescent patients. Additionally, plant-based drugs such as silymarin derived from the seeds of silybum marianum is utilized to treat liver disease, and artemisinin derived from the seeds of artemisia annua is utilized to treat multidrug-resistant malaria. Alkaloids are being repurposed as nitric oxide activators to aid in the prevention of atherosclerosis and obesity. This book is a valuable compilation of topics, 

Plant Based Medicines: Novel Perspectives | Morrison Elise | Copertă tare

Plants are exposed to a number of biotic and abiotic stresses. Soil salinity is one of the major abiotic stresses, which negatively affects plant growth and crop production. Stress due to salinity leads to various changes in the physiological and metabolic processes based on the severity and duration of the stress. In the initial stages, soil salinity leads to osmotic stress, which causes physiological changes such as nutrient imbalance, interruption of membranes, decreased photosynthetic activity, and inhibition of the ability to detoxify the reactive oxygen species. In the later stage, soil salinity leads to ionic toxicity that leads to nutrient imbalance in the cytosol. In order to overcome salinity stress, plants have developed several mechanisms such as ion homeostasis and compartmentalization, ion transport and uptake, generation of nitric oxide NO, and synthesis of polyamines. This book includes some of the vital pieces of works being conducted across the world on various topics

Handbook of Plant Salinity Tolerance | Williams Walker | Copertă tare

An indispensible pocket reference for critical care trainees, consultants and intensive care nurses, this new Oxford Specialist Handbook provides an evidence-based approach to all aspects of patient care in cardiothoracic intensive care. pWritten in the Oxford Handbook format, each section is comprised of short topics ideal for quick reference. Portable, accessible, and reliable, the book equips the clinician with the basic scientific and clinical knowledge to safely assist in formulating management plans, based on current best practice. pemCardiothoracic Critical Careem addresses major recent developments in cardiothoracic critical care, such as cardiovascular support, mechanical support IABP, VADS, and ECMO, and drug therapies such as nitric oxide and other new inotropic agents. The management of postoperative bleeding is covered in detail, as it increasingly involves updated fluid and blood-product therapies including blood preservation techniques such as cell salvage.br

Cardiothoracic Critical Care | Smith Robyn | Copertă tare

pThe book includes several topics as per Universities curriculum of M.Sc. and M.Phil. course work in Chemistry. This covers different Physiological aspects of Bioinorganic Chemistry in terms of 4 Chapters with in-depth and up-to-date coverage. The book symmetrically presents i Coordination chemistry of chlorophyllsbacteriochlophylls and its functional aspects in photosynthesis, ii Complexes containing nitric oxide Synthesis, reactivity, structure, bonding, and therapeutic aspects of nitric oxide releasing molecules NORMS in human beings and plants, iv Complexes containing carbon monoxide Synthesis, reactivity, structure, bonding, and therapeutic aspects of carbon monoxide releasing molecules CORMS in human beings and plants, and iv Advantageous role of gaseous signaling molecule, H2S Hydrogen sulphide and their respective donors, in ophthalmic diseases and physiological implications in plants. At the end, three relevant topics are included as appendices for updating students and facult

Bioinorganic Chemistry: Some New Facets | Maurya Ram Charitra | Copertă tare

pThis book provides an overview of the recent advancements for plant scientists with a research focus on phytohormones and their responses nature, occurrence, and functions in plant cells.ppThis book focuses on the role of phytohormones in biosynthesis, plant sexual reproduction, seed germination and fruit development and ripening. It further highlights the roles of different phytohormones on signaling pathways as well as on photoperiodismGravitropismThigmotropism.ppThe volume also explores the role of phytohormones in gene expression and plant melatonin and serotonin and covers how plant hormones react in case of stressdefence response metalsmetalloidspathogen.pppp Last but not least, this volume also discusses phytohormones in the context of new regulatory molecules such as Nitric oxide, hydrogen sulfide, melatonin.brp

Hormones and Plant Response | Gupta Dharmendra K. | Copertă tare

iMyeloid-Derived Suppressor Cells, Volume 184i in the iMethods in Cell Biologyi series includes comprehensive and detailed protocols to assess the critical role of myeloid-derived suppressor cells MDSCs, an immature, heterogenous cell population from the myeloid lineage with a potent immunosuppressive activity in a variety of diseases. This volume presents twelve interesting protocols that address the isolation of MDSCs in murine models, the detection of mouse and human MDSCs by flow cytometry, T-cell proliferation assays, isolation of MDSC-derived exosomes and their immunosuppressive function, characterization of lysosomal lipase in MDSCs, detection of MDSC-derived nitric oxide, and other iin vivoi and iex vivoi assays.

Myeloid | Derived Suppressor Cells: Volume 184 | Jimnez | Cortegana Carlos | Copertă tare

pb1. bbOverviewbp pb2. bbCell Culture Assaysbp p2.1 Cell Cycle Assay Propidium Iodide Markingp p2.2 Apoptosis Assay Annexin VPropidium Iodide Markingp p2.3 Cytotoxicity in Caco-2 cells by the Alamar blue methodp p2.4 Viability in Caco-2 cells stimulated with lipopolysaccharide LPSp p2.5 Determination of Nitric oxide NO by iin vitro iexperimentp p2.6 Analysis of specific cytotoxicity against RAW 264.7 for determination anti-inflammatory activity iin vitroip p2.7 Scratching of Fibroblast cells scratch assayp p2.8 Evaluation of the in vitro inflammatory response in AGS cellsp pb3. bbPhytochemical Analysisbp p3.1 Preliminary phytochemical assaysp p3.2 Quantitative analysis of secondary metabolitesp p3.3 Thin Layer Chromatography Analysisp p3.4 Analysis by High Performance Liquid Chromatography HPLCp p3.5 Mass spectrometryp 3.6 Electrospray Ionization Mass Spectrometry ESI-MS analysispp p3.7 Identification of phenolic compounds by HPLC-LC-ESI- MSMSp 3.8 Quantitative determination of total a

Bioassays in Experimental and Preclinical Pharmacology | Arunachalam Karuppusamy | Copertă tare

pbSection A Overviewbppb bppb1. bbMediterranean Diet and Skin healthbppLaura Primavesi, Marta Piantanida, Valerio Pravettonipp ppb2. bbImmune mediated disorders of skin-role of dietary factors and plant extracts i ibbi ibbbppbYashwant Kumarbb, and Alka Bhatiabbbppb bppb3. bbUV irradiations, micronutrient supplementation and bbcutaneous health overview bSaeed Hosseini and S. Ali Mostafavibppb bppb4. bbSkin Health and Metabolic Complications bppVijaya Juturub bppb5. bbProbiotics and skin healthbppAudrey Guniche, J. Benyacoub, S. Blum, L. Breton, I. Castielppb bpp ppbSection B Dietary Nutrients and Skin bpp ppb bppb6. b bVitamin C L-Ascorbic Acid Antioxidant involved in skin carebbrRashmi Saini, Sachin L. Badoleb bppb bpp7. bOmega 3 fatty acid in psoriasisbppAman B Upaganlawar, Sachin L. Badole bbppb bpp pp8. bArginine derived nitric oxide Key to healthy SkinbbrRashmi Saini, Sachin L. Badole pp ppb bppb9. bbTaurine 2-aminoethanesulfonic acid Usefbbul in skin diseasesbppSachin L. Badole, S

Bioactive Dietary Factors and Plant Extracts in Dermatology | Watson Ronald Ross | Copertă tare

pbPart I In Vitro and In Vivo Models to Study Photodynamic Therapybp pb bp pb1. Application of Monolayer Cell Cultures for Investigating Basic Mechanisms of Photodynamic Therapybp p Mans Broekgaardenp p p pb2. The Negative Impact of Cancer Cell Nitric Oxide on Photodynamic Therapybp p Jonathan M. Fahey and Albert W. Girottip p p pb3. Microtumor Models as a Preclinical Investigational Platform for Photodynamic Therapybp p Mans Broekgaarden and Jean-Luc Collp p p pb4. A Microfluidic Model to Evaluate Photodynamic Therapy Treatment Response in 3D Tumorsbp p Shubhankar Nath, Michael Pigula, Tayyaba Hasan, and Imran Rizvip p p p5. Analysis of Treatment Effects on Structurally Complex Microtumor Cultures Using a Comprehensive Image Analysis Procedurep p Anne-Laure Bulin, Mans Broekgaarden, and Tayyaba Hasanp p p pb6. High-Throughput Examination of Therapy-Induced Alterations in Redox Metabolism in Spheroid and Microtumor Modelsbp p Mans Broekgaarden, Anne-Laure Bulin, and Tayyaba Hasanp p p 

Photodynamic Therapy: Methods and Protocols | Broekgaarden Mans | Copertă tare

Respiratory diseases are those diseases that affect the lungs and human respiratory system. Some common types of respiratory diseases include asthma, chronic obstructive pulmonary disease COPD, bronchiectasis, bronchitis, pulmonary fibrosis, sarcoidosis, lung cancer and pneumonia. The common signs and symptoms of these diseases are cough, sputum, breathlessness, chest pain, fever, headache, vomiting and nausea, weight loss, and gastro intestinal reflex. Assessment tests such as bronchoscopy, chest tube procedure, CT scan, CT scan guided lung biopsy, endobronchial ultrasound, exhaled nitric oxide test, and lung function tests are performed to diagnose respiratory diseases. The treatments for respiratory diseases include medications, therapies and surgery. Endobronchial valve therapy is a minimally invasive treatment method that improves functioning of the lungs and reduces complications like shortness of breath. Severe cases of respiratory diseases are treated with lung transplantation.

Clinical Manifestations and Assessment of Respiratory Diseases | Rogers Stephen | Copertă tare

Amino acids AAs are not only building blocks of protein, but are also signalling molecules as well as regulators of gene expression and the protein phosphorylation cascade. Additionally, AAs are key precursors for syntheses of hormones and low-molecular weight nitrogenous substances with each having enormous biological importance. For example, physiological concentrations of AA metabolites e.g., nitric oxide, polyamines, glutathione, taurine, thyroid hormones, and serotonin are required for cell functions. Growing evidence shows that humans and animals have dietary requirements for all proteinogenic AAs. Mammals, birds and fish also have species- and age-dependent needs for some AA-related substances. However, elevated levels of other products e.g., ammonia, homocysteine, Hsub2subS, and asymmetric dimethylarginine are pathogenic factors for neurological disorders, oxidative stress, and cardiovascular disease. Thus, optimal amounts of AAs and their ratios in diets and circulation are cr

Amino Acids in Nutrition and Health: Amino Acids in the Nutrition of Companion, Zoo and Farm Animals | Wu Guoyao | Copertă tare

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﻿ Fire moi, de tip chenille, cu ochiuri mari pentru tricotat șaluri sau pături. Nu este nevoie de ace pentru a tricota - doar tricotați cu mâna fiecare ochi individual. Tricotați 1 eșarfă din 3 ghemuri. Tricotați o pătură de 100 x 100 cm cu 5 ghemuri. Se poate spăla la 30 °C. Nuanțele de culoare pot varia ușor în funcție de setările monitorului dumneavoastră.

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Chiuveta bucatarie Schock Toledo D-100XS Cristadur Magnolia 620 x 500 mm, granit, reversibila, montare pe blat, alb cremos - modelul cu 1 cuva si picurator este potrivit pentru copuri de chiuveta de minimum 45 cm. Chiuveta este realizata din material CRISTADUR® cu efect de respingere a murdariei, fara miros (lasa suprafata fara mirosuri), rezistent la caldura pana la 180°C, rezistent la decolorare, usor de curatat, rezistent la impact, sigur in contact cu alimentele si extrem de durabil. Gaura pentru baterie este prefrezata si se face cu ajutorul carotei inclusa in coletul de livrare. Pachetul include garnitura de scurgere, ventil cos, sifon, cleme si carota diamantata.Magnolia: O nuanta la fel de suava si eleganta ca si floarea care ii inspira numele. Aceasta nuanta de alb, cu tente usoare de crem semi-lucios inspira sentimentul de noblete veritabila ce se potriveste perfect intr-o ambianta cu accente romantice si elegante. SCHOCK este inventatorul chiuvetei din granit si este unul di

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Layered's Modular sofa series is a homage to the Italian 70s , combined with the glamour of Milans past. Meanwhile the production and choice of fabric reflect a modern context where sustainability is in focusABOUT THE PRODUCTWe can only ship our furnitures within EU.Handmade in BulgariaThe fabric of the product is not removableAll furniture is delivered assembled, please note that modules are delivered separately which are easily joined together with hooks Separate modules weigh from 15 to 75 kg, sofas from 50-95 kg MATERIAL INFORMATIONVELVET: 100% CottonLINEN LOOK: 75% Polyester, 22% Linen, 3% Cotton, Certified Oeko-TexBOUCLÉ: 45% Cotton, 15% Wool,% Polykarbonat,% Viscose, 8% PolyamideCORD: 48% Polyester, 44% Acetat, 8% Viscose Certifierat Oeko-TexSHEARLING: 100% Polyester, Certifierat Oeko-TexLEATHER: 100% Chrome free Leather

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Acești pantaloni tehnici sunt ușori și multifuncționali, fiind prevăzuți cu ghetre practice. Sunt confecționați dintr-un material subțire și flexibil de poliamidă, cunoscut nu doar pentru durabilitatea sa, ci și pentru capacitatea de a permite pielea să respire. Suprafața pantalonilor este tratată cu un strat hidrofob care respinge umiditatea externă. Am transpus experiența și entuziasmul nostru în acești pantaloni multifuncționali 2 în 1. Pantaloni lungi, cu tiv reglabil și fermoar ascuns, pot fi fixați în siguranță la cizmă. Când deschideți parțial fermoarul, veți permite o mai bună ventilație. În cazul deschiderii complete a fermoarului, puteți obține pantaloni scurți, ideali pentru zilele călduroase, iar partea de jos poate fi folosită ca ghetre reglabile pentru protecție împotriva vegetației sau insectelor. Buzunarele sofisticate de pe coapse sunt perfecte pentru a stoca o hartă, documente sau alte obiecte personale. De asemenea, am adăugat un suport lateral special pentru topor s

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Weleda Pomegranate, 12 ml, Creme și geluri pentru ochi pentru femei, Tratamentul pentru ochi Weleda Pomegranate îngrijește pielea din jurul ochilor, oferindu-i nutriția și hidratarea necesare.  Caracteristici:  netezește liniile și ridurile fine elimină pungile și cercurile întunecate de sub ochi înviorează și netezește zona ochilor  Cum se utilizează: Produsul se aplică în jurul ochilor dimineața și/sau seara, prin tapotare cu degetele, până la absorbție.

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These white track pants have a high waist and a comfy loose fit. They are made from a stretchy functional fabric that is sweat-wicking, quick-drying and highly breathable. They have pockets with hidden zippers on the sides, green panels along the sides and sewn press creases at front. Style the track pants with our white Track Zipped Sweatshirt for a complete look to and from your workouts or casual hangs.

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Cu un design elegant, dar și practic, această bancă de grădină din lemn va fi un element de decor minunat în spațiul dvs. de exterior! Construită din lemn de tec de esenţă tare extrem de rezistent, această piesă de mobilier din tec a fost asezonată, uscată la cuptor și apoi șlefuită fin pentru un aspect foarte neted. Lemnul de tec este cunoscut pentru durabilitatea excepțională și rezistența la intemperii, fiind mult mai potrivit pentru mobilierul de grădină decât orice alt tip de lemn. Lemnul de tec este alegerea perfectă dacă doriți să achiziționați o piesă de mobilier de grădină care să reziste în timp. Această bancă de exterior are un finisaj rafinat, fiind ușor de integrat în orice decor de grădină sau terasă. De asemenea, este ideală pentru momente de relaxare în grădina romantică a unei căsuțe de țară sau lângă un iaz idilic. Perna inclusă este mai mult decât un plus practic; are și o funcție decorativă.Culoare pernă: BejMaterial: Lemn de tec de esență tare, șlefuit fin, cu fini