The anti-ageing solution from Shiseido for +35% more lifting, firming and evenness in just 1 week. Thanks to Japanese expertise in neuroscience, the Uplifting and Firming Advanced Cream is 4x more effective than before. Now also available as a refill!Patented SafflowerREDTM Technology: Shiseido's advanced research has developed a patented ingredient that activates the skin's self-regeneration by boosting its nutrient balance and helping it to fight deep wrinkles and dull skin. Japanese Mogami flowers, grown in the remote countryside of Yamagata in Japan, provide high-quality extracts known for their special properties for the skin.Application: Apply every morning and evening after Vital Perfection LiftDefine Radiance Serum and before Uplifting and Firming Eye Cream.