The Nth-Order Comprehensive Adjoint Sensitivity Analysis Methodology. Volume III Overcoming the Curse of Dimensionality : Springer : 9783031227592 : 303122759X : 13 Apr 2024 : This text describes a comprehensive adjoint sensitivity analysis methodology (C-ASAM), developed by the author, enabling the efficient and exact computation of arbitrarily high-order functional derivatives of model responses to model parameters in large-scale systems. The model's responses can be either scalar-valued functionals of the model's parameters and state variables (as customarily encountered, e.g., in optimization problems) or general function-valued responses, which are often of interest but are currently not amenable to efficient sensitivity analysis. The C-ASAM framework is set in linearly increasing Hilbert spaces, each of state-function-dimensionality, as opposed to exponentially increasing parameter-dimensional spaces, thereby breaking the so-called "curse of dimensionality" in sensitivity and unc