Based on the journals of Cuban revolutionary Ernesto 'Ch' Guevara, this coming-of-age road movie by Brazilian director Walter Salles follows the adventures of the young medical student Ch (Gael Garca Bernal) and his friend Alberto Granada (Rodrigo de la Serna) as they cross South America on motorbikes in the early 1950s, on their way to take up their medical residency at a leper colony in Peru. Along the way, the men discover much about life and about their own views on the world - and begin to realise just how different their individual destinies have become.