Silico Comparative Analysis of Genes Encoding : Independent Self Publisher : 9781805457695 : 1805457691 : 08 Dec 2022 : Methicillin resistant S. aureus (MRSA) is becoming a primary public health consternation all over the world, besides much incremented with its morbidity and mortality among other pathogenic bacteria (Mogahid et al., 2015). Resistance of Staphylococci to methicillin and all ?-lactam antibiotics is associated with the low affinity of a penicillin-binding protein (PBP), PBP2a, which is not present in susceptible staphylococci and is a foreign DNA origin encoded by mecA gene (Petinaki et al., 2001). mecA gene of staphylococcal chromosome also contains the genetic structures such as Tn554, pUB110, and pT181 that has resistance to non-?-lactam antibiotics. In the staphylococcal community, the prevalence of MRSA is predicted to be increased due to horizontal transfer of SCC mec genetic cassette. S. aureus and S. pneumonia are leading causes of hospital and community acqui