Twenty-five years after the original series of murders in Woodsboro, a new killer emerges, and Sidney Prescott must return to uncover the truth. Returning cast Members See the original Scream (1996) cast returning to reprise their roles: Neve Campbell As Sidney Prescott Courteney Cox As Gale Weathers David Arquette As Dewey Riley Meet some of the new faces joining the cast for Scream 2022: Jack Quaid As Richie Kirsch - Best known for portraying Hughie in Prime Video's The Boys Dylan Minette As Wes Hicks - Best known for playing the lead character Clay Jensen in 13 Reason Why