Novel Biosensors Using Intact Liposome Microarrays : 9783639189384 : 01 Sep 2009 : Many of the interactions studied in the biological and biomedical sciences occur with receptors at cell membrane surfaces. Prominent examples are neurotransmitters, cytokine receptors, tyrosine kinase receptors, ligang-and voltage-gated ion channels, G protein-coupled receptors, and antibody receptors. Interactions with these receptors are of special importance not only to academics, but also to the pharmaceutical industry as almost half of the 100 best-selling drugs on the market are targeted to a membrane receptor. More than 50% of current drug targets are membrane bound.Naturally, there is a great interest in development of sensors using membrane proteins for drug discovery and high-throughput screening for detection of pathogens/toxins. This book describes protocols to array individual, intact small unilamellar vesicles (liposomes) onto chemically modified microwell substrates. These arrays can b