Molecular and Cellular Mechanisms of Inflammation and Tissue Regeneration : Mdpi AG : 9783036578989 : 3036578986 : 28 Jun 2023 : Wound healing has three overlapping steps: 1) coagulation and inflammation, 2) the proliferation and formation of new tissue, and 3) tissue remodeling. The initial phase of acute wound healing is the coagulation and the formation of a temporary wound matrix. This phase begins immediately after the injury and is completed within a few hours. Inflammation is crucial to the clean-up-repair process. Early inhibition of inflammation can hinder regeneration processes. Inflammation is associated with the activation of the innate immune system. At the site of inflammation, neutrophils appear first, followed by monocytes, which may differentiate into macrophages. The main function of macrophages and immune cells is to remove cell debris and microorganisms. These cells, in addition to the functions mentioned below, play an essential role in preparing the next phase by