Machine Learning and Knowledge Discovery in Databases. Research Track Lecture Notes in Artificial Intelligence : Springer : 9783030865191 : 3030865193 : 10 Sep 2021 : The multi-volume set LNAI 12975 until 12979 constitutes the refereed proceedings of the European Conference on Machine Learning and Knowledge Discovery in Databases, ECML PKDD 2021, which was held during September 13-17, 2021. The conference was originally planned to take place in Bilbao, Spain, but changed to an online event due to the COVID-19 pandemic.  The 210 full papers presented in these proceedings were carefully reviewed and selected from a total of 869 submissions. The volumes are organized in topical sections as follows: Research Track: Part I: Online learning; reinforcement learning; time series, streams, and sequence models; transfer and multi-task learning; semi-supervised and few-shot learning; learning algorithms and applications. Part II: Generative models; algorithms and learning theory; graphs and