The book will assess the potential role of two medicinal plant Plantago major and Moringa oleifera against CCl4-induced hepatotoxicity in rats. The SOD like activity of the Plantago major and Moringa oleifera extract was performed in Vitro. Some biochemical markers such as alanine transaminase ALT, aspartate transaminase AST, alkaline phosphatase ALP, albumin, total protein, cholesterol, triglycerides and total lipids in serum were investigated. Also, hematological tests including RBCs and WBCs count, hemoglobin level and hematocrit percentage were also investigated. In addition to antioxidant biomarkers such as catalase CAT, superoxide dismutase SOD, total antioxidant capacity TAC, reduced glutathione GSH and the level of lipid peroxidation malondialdehyde, MDA, along with histopathological examination were determined. Results of the present study showed that, CCl4 induced a significant reductions in the total body weights of the intoxicated rats and significant increase in liver-body