pYakir Aharonov is one of the leading figures in the foundations of quantum physics. His contributions range from the celebrated Aharonov-Bohm effect 1959, to the more recent theory of weak measurements whose experimental confirmations were recently ranked as the two most important results of physics in 2011. This volume will contain 27 original articles, contributed by the most important names in quantum physics, in honor of Aharonov's 80-th birthday. pppSections include Quantum mechanics and reality, with contributions from Nobel Laureates David Gross and Sir Anthony Leggett and Yakir Aharonov, S. Popescu and J. Tollaksen Building blocks of Nature with contributions from Francois Englert co-proposer of the scalar boson along with Peter Higgs Time and Cosmology with contributions from Leonard Susskind, P.C.W. Davies and James Hartle Universe as a Wavefunction, with contributions from Phil Pearle, Sean Carroll and David Albert Nonlocality, with contributions from Nicolas Gisin, Daniel