This book is about the author's life motivated by two pursuits medicine, his profession and flyfishing, his favourite recreation. Each in their own way has provided him with challenges, enjoyment and fulfilment.The book recounts the author's experiences as a wartime school boy, post-war medical student, army doctor in Ghana, and medical research worker at Hammersmith Hospital, London, the Massachusetts General Hospital, Boston, the Methodist Hospital, Houston and McGill University, Montreal. It describes his drastic change in mid-career from gastroenterology to clinical lipidology and his subsequent efforts to promote the lipid hypothesis of atherosclerosis in the face of entrenched opposition from some members of the cardiological establishment. Among his achievements was the introduction of plasmapheresis to prolong the lives of severely affected patients with familial hypercholesterolaemia FH, a hitherto fatal disorder, and he was among the first to describe the efficacy of statins