Isotope Dilution Mass Spectrometry IDMS is increasingly used in research laboratories and has become an essential tool in routine analysis labs including environmental and clinical applications. This is the first textbook to present a comprehensive and instructive view of the theory and applications of this growing technique. Postgraduate students and laboratory staff will find this textbook to be a highly accessible guide to isotope dilution analysis, providing the reader with a sound basis to working with this technique. Experienced researchers will benefit from designing experiments with IDMS methodologies in mind. The authors enjoy a strong reputation in the field of analytical chemistry and the reader will be familiar with their previous research.