The purpose of this book is to narrate important, dynamic events that have taken place in the Indo-U.S. relations, beginning from 1943 to 2013. This includes the American role in India's independence, the Cold War, demise of the Soviet Union, resurgence of Islamic fundamentalism, terrorists' attack of American cities in 2001, decline of American power, rise of India, and rise of China. The study is confined to only three areas terrorism, nuclear proliferation, and nuclear energy. The defining moment of the twenty-first century occurred in 2008 when these two estranged great democracies engaged one another to work on common goals and establish a strategic relationship between two natural allies.