pThis volume explores homologous recombination's HR essential role in meiotic and somatic cells. It discusses the analysis of different steps of the HR process from the genetic, molecular biology, and cell biology perspectives. Using a variety of model systems, chapters in this book cover topics such as the genome-wide mapping of DNA double-strand breaks DSB analysis of DNA-end resection and recombination intermediates by gel electrophoresis and southern blotting cell-based monitoring of HR activity in meiotic and mitotic cells in vitro analysis of branch migration, DNA strand exchange and Holliday junction resolution or super resolution imaging of HR repair at collapsed replication forks. Written in the highly successful iMethods in Molecular Biologyi series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. pC