This book constitutes the refereed proceedings of the 13th EAI International Conference on Practical Aspects of Digital Forensics and Cyber Crime, ICDF2C 2022, held in Boston, MA, during November 16-18, 2022.brThe 28 full papers included in this book were carefully reviewed and selected from 80 submissions. They were organized in topical sections as follows Image Forensics Forensics Analysis spread spectrum analysis traffic analysis and monitoring malware analysis security risk management privacy and security.