pThe increased use of non-inferiority analysis has been accompanied by a proliferation of research on the design and analysis of non-inferiority studies. Using examples from real clinical trials, strongDesign and Analysis of Non-Inferiority Trialsstrong brings together this body of research and confronts the issues involved in the design of a non-inferiority trial. Each chapter begins with a non-technical introduction, making the text easily understood by those without prior knowledge of this type of trial. ppppstrongTopics covered include strongpppul ppp liA variety of issues of non-inferiority trials, including multiple comparisons, missing data, analysis population, the use of safety margins, the internal consistency of non-inferiority inference, the use of surrogate endpoints, trial monitoring, and equivalence trialsli pliSpecific issues and analysis methods when the data are binary, continuous, and time-to-eventli pliThe history of non-inferiority trials and the design and conduct