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Myprotein

Nutritional information may vary depending on flavour.  L-tyrosine is a naturally occurring amino acid that can be found in small amounts in a range of foods. Getting it from your diet can be costly and time consuming, so weve created a convenient powder that can be easily added to your daily smoothie or shake.           Performance Advisory Board  Bringing together world-class scientists, doctors, and athletes to shape innovation at Myproteincombining cutting-edge research with real-world testing to create solutions that actually deliver, for everybody. Find out more about our Performance Advisory Board.

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Higher Nature

'What is Thyroid Support Formula?Our Thyroid Support Formula provides essential nutrients that are key to thyroid health. These include the amino acid tyrosine, iodine, selenium and zinc,along with nine other essential nutrients. The thyroid gland plays a major role in our metabolism, growth and development. It can however be affected by factors including long term stress, nutrient deficiencies, toxicity and certain medications. Possible symptoms of an underfunctioning thyroid may include fatigue, weight gain, sensitivity to the cold and constipation. This complex has been designed to support healthy thyroid function.Why is ours better?The Thyroid Support Formula provides key nutrients for thyroid hormone production including tyrosine, iodine and selenium along with 9 other vitamins and minerals in a vegetarian and vegan-friendly complex.Who is this for?Anyone wishing to support the normal functioning of the thyroid. In some instances, the thyroid may not be working at an optimal level

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Zooplus

Your dog's coat is a good indicator of its well-being. Royal Canin Coat Care Loaf has been specially developed for dogs with a dull or lustreless coat. The formula contains high-quality borage oil, which is particularly rich in omega-3 and -6 fatty acids, including valuable gamma-linolenic acid. These can contribute to a shiny coat and normal skin. Royal Canin Coat Care Loaf also serves as a source of tyrosine and phenylalanine, which, as melanin precursors, can support the colour pigmentation of the coat. Thanks to the soft mousse texture, the wet dog food is readily accepted. Royal Canin Coat Care Loaf at a glance: Complete wet food for adult dogs aged 10 months and over Skin and fur: gamma-linolenic acid and other omega-3 and -6 fatty acids from borage oil can contribute to normal skin and a shiny coat Natural coat colour: exclusive formula with melanin precursors tyrosine phenylalanine, can promote colour pigmentation Holistic: with important minerals, vitamins proteins Velvety mou

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Lamberts L-Tyrosine 500mg 60 capsules: Express Chemist offer fast delivery and reliable service. Buy Lamberts L-Tyrosine 500mg 60 capsules online from Express Chemist today!

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Get ready for the ultimate team-up. Whether you're prepping for an intense workout or simply gearing up for the day, the Deadpool x Wolverine Bundle has got you covered.Power up your sessions with your choice of pre-workout, inspired by two of MARVEL's fiercest icons, then mix and match it with an ultra-durable metal shaker.What's in the bundle?1x Impact Pre-Workout (Wolverine or Deadpool)A powerful pre-workout blend packed with a whole host of widely researched and trusted ingredients - including L-tyrosine, beta-alanine, and caffeine to help you tear through any workout, no matter how tough.Choose your hero and take your training to the next level.1x Shaker (Wolverine or Deadpool)Mix up your pre-workout with the style that suits you best. Whether it's Deadpool's chaotic charm or Wolverine's raw intensity, these shakers don't just look good - they're built for action.1. Caffeine contributes to an increase in endurance performance and capacity. Caffeine helps to improve concentration a

Deadpool & Wolverine Bundle - Deadpool Shaker - Deadpool

Deadpool & Wolverine Bundle - Deadpool Shaker - Wolverine

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ENbook.hu

pGrowth factor receptors have long been known to drive malignant transformation and cancer progression. The epidermal growth factor receptor EGFR, ErbB, HER system is likely the best described membrane receptor tyrosine kinase family in malignant tumors. With implementation of the growth-inhibitory anti-HER-2 antibody trastuzumab Herceptin for the treatment of HER-2-positive advanced metastatic breast cancer, a new era has dawned in the therapy of this malignant disease. Unfortunately, trastuzumab-sensitive cancers invariably develop resistance to the antibody after some time. Recent clinical studies have revealed that these refractory tumors are still responsive to inhibition of the HER receptor family using dual HER-1-2 inhibitors such as lapatinib TykerbTyverb. Moreover, a multiplicity of novel, improved irreversibly acting small molecular HER tyrosine kinase inhibitors are in the pipeline of many drug developing companies and are being evaluated in the clinical setting.p

Drugs for HER | 2 | Positive Breast Cancer | Sibilia Maria | Keménykötésű

Bodyworld

Az L-tirozin egy nem esszenciális aminosav, melynek jelenléte pozitívan befolyásolja az anyagcserét. Normál körülmények között a szervezet képes L-fenilalaninból L-tirozint elállítani, de megerltetfizikai aktivitás során vagy étkezési hibák következtében hiány léphet fel, ezért ilyenkor célszerezt az aminosavat pótolni.

Nutrend Tyrosine 120 kapszula

In this volume, the specific challenges and problems facing the evaluation of new oncology agents are explored with regards to pharmacokinetic, pharmacodynamic modeling and clinical pharmacology development strategies. This book delivers, with an emphasis on the oncology therapeutic area, the goals set in the first three volumes namely - to provide clinical pharmacologists practical insights for the application of pharmacology, pharmacokinetics and pharmacodynamics for new drug development strategies. Pharmacokinetic-pharmacodynamic concepts for tyrosine kinases, the evaluation of cardiac repolarization prolongation through QTc interval effects, efficacy- and safety-response analyses to support new drug approvals, clinical and preclinical tumor growth modeling, and flat- vs weight-based dose selection are showcased from an oncology clinical pharmacologist's point-of-view. Oncology development strategies are surveyed for new FDA-approvals to identify patterns in expectations at time of 

Pharmacokinetics in Drug Development: Problems and Challenges in Oncology, Volume 4 | Bonate Peter L. | Keménykötésű

pConventional lung cancer treatments were once limited to surgery, radiation, and chemotherapy. However, gefitinib, a targeted drug, was launched in 2004, and the situation changed. Cancer cases that were highly responsive to gefitinib were later discovered to have epithelial growth factor receptor EGFR mutations. This discovery opened the door for biomarker-based treatment strategies. Subsequently, several EGFR-tyrosine kinase inhibitors TKI were developed, and they became a new mainstay of treatment for non-small cell lung cancer. In recent years, many mechanisms of resistance to EGFR-TKI have been elucidated a mutation in the emT790Mem gene at exon 20 is found in half of the resistant cases. Hence, osimertinib, which specifically inhibits EGFR despite this emT790Mem gene mutation, was developed to achieve long-term progression-free survival. Other driver mutations that are similar to the EGFR mutation were discovered, including the emEML4-ALKem fusion gene discovered in 2007, emROS1

Non | small Cell Lung Cancer: Current Therapies and New Targeted Treatments | Uchino Junji | Keménykötésű

Epidermal growth factor receptor EGFR-mutant non-small cell lung cancer NSCLC is a clinically important driver alteration affecting approximately one-third of lung cancer patients. Treatments for EGFR-exon 19 deletion and exon 21 L858R NSCLC have evolved over the last decade from first-generation reversible tyrosine kinase inhibitors TKI to third-generation irreversible TKIs, of which osimertinib has been the widely accepted as first-line therapy. Despite survival improvement seen with osimertinib and its efficacy against acquired T790M mutation, resistance through on-target and off-target pathways eventually develop. This Element describes the structural biology and pathophysiology of EGFR-mutant NSCLC and discusses past, current, and future treatment options in the metastatic, neoadjuvant, and adjuvant settings. It describes the biology and recently approved treatment for EGFR-exon 20 insertion mutation and the treatment for the uncommon exon 18 G719X, 20 S768I, and 21 L861Q mutation

Egfr | Directed Therapy in Lung Cancer | Kim So Yeon | Keménykötésű

pOverexpression of receptor tyrosine kinases RTKs has been implicated in cancer. Increasing evidence suggests that dysregulation of RTKs is reported in many neurodegenerative and psychiatric disorders.p piReceptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disordersi provides a fundamental, pragmatic map of RTKs structure, activation, functions, mechanism of action, gene regulation, and signaling pathways in developing CNS, adult normal CNS, neurodegenerative and psychiatric disorders. Additionally, the structure, function, activation, and therapeutic potential of many growth factors have been covered. Here, international experts in the field offer a comprehensive discussion of results of pre-clinical and clinical studies of repositioning of anti-cancer receptor RTKIs and other promising protein kinase inhibitors in various neurodegenerative disorders including, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, Huntington's disease, and multiple sclero

Receptor Tyrosine Kinases in Neurodegenerative and Psychiatric Disorders | Mansour Heba Mohamed | Keménykötésű

This critical review volume explores the theme of ABC transporters in the context of basic cancer research and its role in drug-resistant tumors. The chapters provided complement basic research by including investigations from translational applications to clinical oncology. The development of resistance is a major obstacle in cancer chemotherapy and the field has been moving rapidly in terms of determining the mechanisms for blocking ABC transporter-mediated drug efflux by specific inhibitors and thereby overcoming multidrug resistance. The volume covers these issues in careful detail. Additional topics include the relevance of ABC transporters in resistance to novel and established anticancer drugs and prognosis of patients to compounds, compounds used in photodynamic therapy, tyrosine kinase inhibitors and others. Furthermore, the potential of radiopharmaceuticals for diagnosis of multidrug-resistant tumors and of nanotechnology to combat drug-resistant tumors is also discussed.

Resistance to Targeted ABC Transporters in Cancer | Efferth Thomas | Keménykötésű

pFibroblast growth factor FGF signal transmission has an essential function in embryonic development and tissue repair, and is dysregulated in the vast majority of malignancies studied. The FGF signaling in the tumor cells is usually increased by autocrine and paracrine mechanisms and gives them a high growth potential, resistance to apoptosis, neoangiogenesis and metastasis, all essential parameters relevant for tumor progression. This makes FGFs, and their tyrosine kinase receptors FGFRs, valuable targets for therapeutic interventions. This book is a collection of 15 recent articles-both original work and reviews-that summarize the current research state effectively. The content covers FGF signaling aspects in gastric, skin, liver, esophageal cancer, melanoma, mesothelioma and glioblastoma, including one article that addresses the role of FGF in the tumor-microenvironment cross-talk. Several reports describe the development of compounds targeting FGFRs, their structure and interactio

Fibroblast Growth Factor Receptor FGFR Signaling Pathway in Tumor | Holzmann Klaus | Keménykötésű

Receptor tyrosine kinases are a large family of cell-surface receptors that respond to a variety of intercellular signals, including insulin, growth factors such as epidermal growth factor EGF and fibroblast growth factor FGF, and molecules involved in neuronal guidance. Ligand bindingbrstimulates the tyrosine kinase activity of the receptors, leading to recruitment of enzymes and adapter proteins that activate intracellular signaling pathways that control cell proliferation, differentiation, and numerous other biological processes. pWritten and edited by experts in the field, this collection from Cold Spring Harbor Perspectives in Biology discusses the mechanisms underlying receptor tyrosine kinase signaling, including ligand processing, receptor dimerization, receptor trafficking, and the roles of adapters. The contributorsbralso survey the specific functions of the different subfamilies of receptors and examine their many roles in development and normal physiology. pIn addition, the

Signaling by Receptor Tyrosine Kinases | Schlessinger Joseph | Keménykötésű

bWhen the village you call home exists alongside the most dangerous dungeon in the land, the word iweak iis completely relative in this manga adaptation of the popular light novel series!b pThe Jiou Empire has secretly taken control of Rokujo Kingdom! When King Sardin Valyl-Tyrosine sends out an SOS, Lloyd and his friends are dispatched to Rokujo--to be extras in a movie! Alka casts a spell to make him look older, and Lloyd auditions for a role--but nobody expected him to land a leading part! Even on the silver screen, he stumbles his way to success!

Suppose a Kid from the Last Dungeon Boonies Moved to a Starter Town 11 Manga | Satou Toshio | Keménykötésű

pUbiquitination is a biological process mediated by ubiquitin itself, the E1 ubiquitin-activating enzyme, E2 ubiquitin-conjugating enzyme, E3 ubiquitin ligase, and deubiquitinating enzyme, respectively. Currently, these multiple biological steps are revealed to participate in various life phenomena, such as cell proliferation, regulation of cell surface proteins expression, and mitochondrial function, which are profoundly related to human health and diseases. Although clinical applications targeting ubiquitination are still limited compared to those directed toward kinase systems such as tyrosine kinases, multiple enzymatic consequences should be future therapeutic implications. This Special Issue of IJMS entitled Ubiquitination in Health and Disease successfully published15 distinguished manuscripts, with a total of 66 international authors and. This book provides the latest and most useful information for researchers and scientists in this field.p

Ubiquitination in Health and Diseases | Ishigami Tomoaki | Keménykötésű

pDo you believe that low protein food is tasteless, hard to cook, repetitive or impossible to serve to all your guests, unless you want to disappoint them This recipe book will prove you wrong  Delicious and attractive recipes are presented in these pages, for great occasions, but also for daily meals. Plus, those recipes will please everyone around the table  This book regroups recipes into different categories such as Christmas, the Superbowl, girl's night, sugar shack, and pasta sauces. These recipes are proof that it can be easy and most importantly delicious to restraint your protein intake.pp ppThese recipes suggest numerous ways to use low protein ingredients that are easily found at the grocery store, and how to integrate them to your routine while diversifying your meals. Furthermore, nutritional values have been calculated in order to give you the precise amount of calories, proteins, phenylalanine, tyrosine, and leucine. This book regroups recipes into different categories s

Low Protein Recipes | LaFrance Rd Genevive | Keménykötésű

pThis volume discusses different enzyme-catalyzed ligation methodologies for a variety of different chemical transformations. This book wants readers to view enzymes as a powerful tool in both academic and industrial research. Chapters in this book cover topics such as sortase A-mediated generation of site-specifically conjugated antibody-drug conjugates omniligase-catalyzed inter- and intramolecular ligation ligation catalyzed by microbial transglutaminase peptide cyclization mediated by cyanobactin macrocyclases, butelase 1 and sortase A using BioID as a tool for protein proximity labeling in living cells and inducible, selective labeling of proteins via enzymatic oxidation of tyrosine. Written in the highly successful iMethods in Molecular Biologyi series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. pCu

Enzyme | Mediated Ligation Methods | Nuijens Timo | Keménykötésű

La vaccination est le moyen le plus efficace de lutte contre les infections grippales mais les adamantanes et les inhibiteurs de neuraminidase INAs ont egalement prouve leur efficacite. Jusqu'a present, une faible resistance aux INAs etait observee mais de recentes etudes revelent une forte prevalence de virus AH1N1 resistants a l'oseltamivir en Europe. En position 274 du gene de la neuraminidase N1, une tyrosine remplace une histidine H274Y et confere un haut niveau de resistance a l'oseltamivir. De janvier a avril 2008, 21 souches isolees de patients vus en consultation de ville et hospitalises ont ete analysees par sequencage. Une RT-PCR en temps reel technologie FRET a ete developpee pour detecter rapidement la mutation H274Y. Celle-ci a ete mise en evidence dans la sequence du gene N1 de 10 isolats 48. Les resultats de RT-PCR en temps reel et de sequencage concordent parfaitement avec les donnees des tests phenotypiques realises dans un laboratoire de reference et correspondent au

Rsistance Des Souches Grippales Ah1n1 L Oseltamivir | Burrel | S | Keménykötésű

pThis volume of emPharmaceutical Biocatalysisem starts with a discussion on the importance of biocatalytic synthesis approaches for a sustainable and environmentally friendly production of pharmaceuticals and active pharmaceutical ingredients. Among the enzymes discussed in detail with respect to their pharmaceutical relevance are cyclic nucleotide phosphodiesterases playing an important role in modulating signal transduction in various cell types human DOPA decarboxylase, related to Parkinson's disease and aromatic amino acid decarboxylase deficiency and phospholipase D enzymes as drug targets. Isocitrate dehydrogenase 1 and 2 mutations are novel therapeutic targets in acute myeloid leukemia. An additional chapter is devoted to the use of enzymes for prodrug activation in cancer therapy. The other topics include small-molecule inhibitors targeting receptor tyrosine kinases in cancer, 946-Lactams and related compounds as antibacterials, non-vitamin K oral anticoagulants for the treatme

Pharmaceutical Biocatalysis: Important Enzymes, Novel Targets, and Therapies | Grunwald Peter | Keménykötésű

Protein kinases are enzymes that use ATP to phosphorylate other proteins, which results in the alteration of their functions. These are signaling enzymes, which are responsible for regulating signal transduction in multiple intracellular processes such as glycogen synthesis, hormone responses, ion transport, proliferation, apoptosis, metabolism, transcription and antibiotic resistance. There are more than 30 families of kinases, of which protein kinase family is the largest. A few examples of protein kinases include AMP-activated protein kinase AMPK, calcium calmodulin dependent kinases CAMK, AGC kinase, casein kinase 1 CK1, CMGC kinases, tyrosine kinases TKs, and receptor interacting protein kinases RIPKs. AMPK affects some major physiological functions such as metabolic activity. AMPKs are also critical for regulating lipid metabolism, mitochondrial function, and carbohydrate metabolism. This book includes some of the vital pieces of works being conducted across the world, on various

Protein Kinases: Molecular Insights | Graham Bailey | Keménykötésű

4Home

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Curaprox Regular Refill CPS 14, 5 db, Tartalék fogköztisztító kefe  férfiaknak, A praktikus Curaprox Regular Refill CPS 14 fogköztisztító kefe pótfej a régi helyére tehető és így ismét garantált a szájüreg tökéletes ápolása.  Tulajdonságok:  a régi fogkefefej lecserélésére szolgál tökéletesen eltávolítja a szennyeződéseket a fogak közötti hézagokból csökkenti a fogszuvasodás kialakulásának veszélyét meggátolja a fogínygyulladás és a kellemetlen szájszag létrejöttét könnyen cserélhető  Használata: Cserélje le a régi kefefejet a pótfejre. Helyezze a fogkefét a fogközbe, majd előre és hátra mozgatva tisztítsa meg.

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A Hill's Science Plan Adult Sterilised kiegyensúlyozott, zsírszegény nedves eledelt kifejezetten a fiatal, ivartalanított macskák táplálkozási igényeinek megfelelően fejlesztették ki. Ivartalanítás után a macskák hajlamosak az elhízásra. Az ivartalanítás következményeként lassul az anyagcsere és növekszik az étvágy, miközben a tényleges energiaszükséglet csökken.A Hill´s L-canitinnel kiegészített súlykontroll-formulája segíti a macskát abban, hogy megtartsa ideális testtömegét. Az eledel ellenőrzött ásványi anyag tartalma támogatja a húgyutak normál működését. Ezenkívül fontos aminosavakat is tartalmaz, mint például L-lizint, mely különböző testi funkciókhoz szükséges. A csirke és a lazac finom íze teszi a Hill's Science Plan Adult Sterilised Cat eledelt zamatos csemegévé.Hill's Science Plan Adult Sterilised jellemzői röviden: Teljes értékű eledel fiatal felnőtt macskák számáraKifejezetten az ivartalanított macskák táplálkozási és energiaigényeire szabvaSúlykontroll-formula: alacsony z