pprodigiosin marine viva autophage oral squamous cell carcinoma Jaspine B bile salts intestinal permeability bioavailability metabolic instability edible brown algae protein enzymatic hydrolysate ultrafiltration ACE-inhibition antioxidant properties phlorotannins peptide fractions amino acids composition marine functional foods cardiovascular-health iPachyclavulariai octocoral cembrane briarane briarellin secosterol bioactivity hepatic stellate cells iPinnigorgiai sp. ROS apoptosis caspase-3 MAPK sulfated galactan 3T3 fibroblasts green seaweed radiation pneumonitis lung fibrosis fucoidan cytokine macrophage neutrophil neolignan iLumnitzera racemosai anti-angiogenesis anti-inflammation phomaketide A lymphangiogenesis lymphatic endothelial cells vascular endothelial growth factor receptor-3p