This monograph is motivated by a number of recent developments that appear to define a possible new role for researchers with an engineering profile. First, there are now several software libraries - such as IBM's Qiskit, Google's Cirq, and Xanadu's PennyLane - that make programming quantum algorithms more accessible, while also providing cloud-based access to actual quantum computers. Second, a new framework is emerging for programming quantum algorithms to be run on current quantum hardware quantum machine learning.p pIn the current noisy intermediate-scale quantum NISQ era, quantum machine learning is emerging as a dominant paradigm to program gate-based quantum computers. In quantum machine learning, the gates of a quantum circuit are parametrized, and the parameters are tuned via classical optimization based on data and on measurements of the outputs of the circuit. Parametrized quantum circuits PQCs can efficiently address combinatorial optimization problems, implement probabilis