First edition of Jacob Mantino's translation into Latin of the fourth part of the first book of Ibn Sina's Canon of Medicine (original title: al-Qanun fi at-Tibb), divided into 31 chapters. Mantino dedicated it to the Doge of the Venetian Republic, Andrea Gritti (1455-1538).Jacob Mantino (1490-1549) was a Jewish doctor, rabbi and philosopher. He was born in Spain, but he, his family and the Jewish community in Tortosa were forced to flee after refusing catholic baptism, as decreed by the catholic King Ferdinand II and Queen Isabella I of Spain. Mantino grew up in Italy and studied philosophy and medicine at the universities of Bologna and Padua. Most of his adult life was spent being a doctor to the pope and other prominent members of society like cardinals, bishops and ambassadors in Bologna, Verona, Venice and Rome. He was also involved in the (religious) controversy over Henry VIII's divorce from Catharine of Aragon. In 1549, just before his death, he moved to Damascus as ambassador